Pope Alexander tasks Cardinal Sforza with initiating an inquisition among the Cardinals who were politicking against him. With the evidence he needs, Alexander dismisses and banishes all the Cardinals he does not trust. Meanwhile, Catherina Sforza orders Rufio to seek support from the mercenary warlords of the Romagna families. Lucrezia is annoyed with her in-laws to be and her situation is complicated further as she realizes her feelings for Cesare are becoming something more than sisterly.